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KMID : 1011920120130020008
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International Journal of Arrhythmia
2012 Volume.13 No. 2 p.8 ~ p.13
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Mechanism of arrhythmogenesis
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Pak Hui-Nam
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Abstract
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Arrhythmia is associated with complex background mechanisms of reentry, automaticity, and triggered activity. Arrhythmia results from interplay among these 3 mechanisms, based on ion channel function and calcium dynamics. In addition to cellular electrophysiology, conductance between cardiomyocytes and interstitial tissue, such as gap junctions or fibrosis, and mechanoelectrical feedback may also play important roles in arrhythmogenesis.
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KEYWORD
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arrhythmogenesis, calcium, fibrosis, gap junction, ion channel
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